If A is detectable by SCiO in the presence of CDE, and B is correlated with A, then B should also be detectable by SCiO.
SCiO’s algorithms do not use any information other than the spectra and the reference data, if there’s correlation between the reference data and the processed spectra – the algorithms should be able to find it.
Please feel free to reach out to us at dev@consumerphysics.com if you have specific questions about your experiment and we’ll be happy to advise if we can.